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BioE Seminars Spring 2021: Programming Medical Treatment One Nanolayer at a Time
Paula T. Hammond
Department Head
David H. Koch Professor
Department of Chemical Engineering
MIT

Abstract: By alternating positively and negatively charged molecules in sequence, it is possible to generate thin films one nano-layer at a time while controlling the composition of the film with great precision. This electrostatic layer-by-layer (LBL) process is a simple and elegant method of constructing highly tailored ultrathin polymer and organic-inorganic composite thin films. We have used this method to develop thin films that can encapsulate and release proteins and biologic drugs such as growth factors with highly preserved activity from the surfaces of biomedical implants or wound dressings with sustained release over periods of several days. We have engineered coatings that yield release of different drugs, DNA or protein, resulting in highly tunable multi-agent delivery nanolayered release systems for tissue engineering, biomedical devices, and wound healing applications. Depending on the nature of the LbL assembly, we can generate thin films that rapidly release proteins or peptides within minutes for rapid hemostasis to stop bleeding in soldiers on the battlefield, or release growth factors that help to regenerate bone in defects where bone may no longer grow. Finally, the manipulation of charge to target other tissues, in particular cartilage, is an important means of targeting the joint for osteoarthritis. We have generated unimolecular charged systems that can be precisely tuned to achieve deep penetration into avascular tissues such as cartilage to enable extended release treatments for cartilage regeneration. These and other uses of controlled polyelectrolytes and their complexes for delivery within tissues and across barriers will be addressed. We also have developed a modular nanoparticle approach using liposomal core particles and layering them with an electrostatic layer-by-layer (LBL) process in a simple and elegant method of const

Apr 28, 2021 12:00 PM in Pacific Time (US and Canada)

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